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Ebba Nex is an esteemed expert in the field of B12 with many publications in her name and is Professor emerita at Aarhus University Hospital, Department of Clinical Medicine where she is involved in research in various aspects of mainly biomarkers for B12 status

(2018) Surplus vitamin B(12) use does not reduce fatigue in patients with irritable bowel syndrome or inflammatory bowel disease: A randomized double-blind placebo-controlled trial

A balanced diet and regular health checks are also important

NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)

This reduces potential confounding factors in research and provides a highly specific tool for metabolic studies